Since the first successful clinical in situ allogeneic heart transplantation in 1967, more than 300 heart centers worldwide have performed a total of more than 50,000 heart transplants in more than 30 years. With the accumulation of clinical experience, increasingly mature surgical techniques; in-depth research in physiopathology, and the successful use of immunosuppressive agents, the results of heart transplantation have become increasingly better, with five-year survival rates of more than 80% and 10-year survival rates of more than 50%. In many heart centers around the world, heart transplantation has become a routine treatment to save patients with end-stage heart failure. China’s heart transplantation work started late and has a large gap with the international community. Since the beginning of the 1990s, about 100 heart transplants have been performed nationwide, with relatively small-scale efforts in Fujian, Shanghai and Harbin. In general, heart transplantation in China lags behind other types of organ transplantation, such as kidney transplantation, liver transplantation, bone marrow transplantation, etc. On the other hand, compared to the actual situation of a large population base and a large number of patients with end-stage heart failure, heart transplantation in China is still far from meeting the requirements of patients. Requirements for donor organs: Most of the donors for foreign organ transplants come from brain-dead patients, and the limited source of donors has constituted the biggest obstacle affecting the number of organ transplants, so developed countries have adopted networks to effectively use donor organs. There is no brain death legislation in China until now. This is one of the most important reasons for the lag in heart transplantation in China. Therefore, it is especially important to use donor organs rationally and effectively. The requirements for heart transplant donor selection include: 1, preferably under 50 years of age, no history of heart disease; 2, no malignant tumors, no HIV, negative for various hepatitis virus antigens; 3, no active systemic infections; 4, the same blood type as the recipient, negative for human lymphocytotoxin cross-test; 5, matching weight and height, weight matching is more important than height, the weight of the donor can be 20% lighter than the recipient, and can be 50% lighter than the recipient’s weight; 6. The donor’s weight can be 20% lighter than the recipient’s weight or 50% lighter than the recipient’s weight; 6. The size of the heart shadow on the chest X-ray of the donor and recipient matches; 7. After brain death, the heart organ is taken with stable circulation, normal heartbeat and no heart damage. The quality of the donor heart is directly related to the success of heart transplantation. In addition to the above requirements, the site conditions where the donor heart is taken must be as clean as possible and conducive to aseptic operation. Since the effective protection time of the isolated heart is limited (generally no more than four hours of ischemia), the closer the heart-taking site is to the transplantation hospital, the better, and the drive should be kept within one hour and no more than two hours at most. Due to the high requirements for the donor heart (including stable circulation, normal heartbeat, no heart damage, aseptic operation, etc.), if a combination of donor organs is used, the principle that the heart is taken first should be ensured, and cannot be taken at the same time as the liver, kidney, and other organs to avoid mutual influence.