Surgical resection is the first choice of tumor treatment method, and liver cancer is no exception. However, liver function in cirrhosis is generally very poor, even in the compensatory stage without portal hypertension and ascites, it is difficult to withstand the blow of surgical trauma, after all, surgery is too traumatic to the liver. Because of the underlying disease of cirrhosis, the patient’s liver tumor is removed, and it is difficult to recover from the postoperative liver failure. Liver cancer is a systemic disease, and the removal of localized liver cancer does not mean that the systemic cancer gene is eliminated, and it still has the possibility of growing again, so the recurrence rate is very high. The modern medical profession believes that the treatment of liver cancer should be a comprehensive treatment of the whole body, and changes the direction of “treating the disease” to “treating the person”, with the highest medical purpose of improving the quality of life of the patient being people-oriented. It is to let patients have a comfortable treatment and happy life, and not to let them have a painful treatment and painful life. Based on the above view, the method chosen for the treatment of cirrhotic liver cancer should be to choose the method that is less invasive and can achieve the treatment purpose —– interventional treatment. For example, arterial catheter embolization under radiation (radiation intervention), radiofrequency ablation under ultrasound guidance, microwave ablation and the most promising method of argon helium knife ablation, all of these treatments do not require incision to remove the tumor and are basically needle-based treatment methods, which are less traumatic to the liver and have faster recovery, and are not as strict as surgery in terms of liver function requirements. Gamma knife, radioactive particle implantation is also an optional treatment method with little damage. However, these methods do not cover all types of post-cirrhotic liver cancer patients, but also have their therapeutic scope, which should be carefully and scientifically selected in clinical practice. In conclusion, the overall plan should be considered when treating cirrhotic liver cancer: a systemic comprehensive and least traumatic approach that can achieve the treatment purpose.