New coronavirus pneumonia is novel coronavirus pneumonia, referred to as new coronavirus pneumonia. The mutant strains currently seen in neo-coronavirus pneumonia include Delta, Ramada, Alpha, Beta, Gamma, etc. The clinical symptoms of mutant strains are generally not specific and it is difficult to identify the strains from their clinical manifestations. Most of the symptoms of infection with mutant strains of Neocrown pneumonia may be fever, dry cough, malaise, and also muscle pain, chest tightness, sore throat, headache, nasal congestion, runny nose, etc. There may also be loss of appetite, diarrhea, and impaired sense of smell and taste. Severely infected individuals may also present with respiratory distress, hypoxemia, and even acute respiratory distress syndrome, septic shock, and multi-organ failure, and very rarely, central nervous system involvement. Delta is the most transmissible of the mutant strains identified so far, with a shorter incubation period than the original strain, a high viral load, and a rapid onset of disease. The mutant strain is more widespread in the world and may have additional symptoms that have not yet been identified. Also, because these symptoms are common in a variety of diseases, it is difficult to differentiate the diagnosis from the new coronavirus variant. When uncomfortable symptoms are present and there is a possibility of previous exposure to a person with New Coronavirus infection, early access to a fever clinic at a designated health care facility should be used to determine if the infection is a variant strain through clinical testing. In addition, for the control of New Coronavirus infection and the emergence of mutant strains, universal vaccination against New Coronavirus is needed for prevention and control, and good personal protection during the epidemic, both to protect oneself and to protect others. In addition to wearing masks, washing hands regularly, ventilating, reducing gatherings, and maintaining social distance, one should pay more attention to the recent changes in the New Crown pneumonia epidemic, etc.