Although the pathogenesis of osteoporosis and osteoarthritis are very different, a large number of clinical studies have shown that the incidence of osteoarthritis in patients with osteoporosis is quite high, in which estrogen and vitamin D deficiency are able to further aggravate the condition of osteoarthritis. Therefore, strengthening the treatment and prevention of osteoporosis can, to a certain extent, reduce or alleviate the clinical symptoms of osteoarthritis. Osteoporosis prevention mainly includes: maintaining a healthy mind, reasonable diet, proper exercise, not smoking and drinking, participating in outdoor activities regularly, and getting more sunlight. For patients with more serious osteoporosis, some calcium supplements, active vitamin D, bisphosphonates, salmon calcitonin, etc. can be taken appropriately for postmenopausal patients with osteoporosis, and some estrogens can also be taken appropriately.