Pain is the most common and main symptom of osteoporosis. It is because excessive bone conversion, increased bone resorption, destruction and loss of bone trabeculae, and destruction of subperiosteal cortical bone can all cause generalized bone pain. Among them, low back pain is the most common. Treatment principles: a. Delay the loss of bone mass and increase bone storage b. Medication: 1. calcium and vitamin D calcium 1 – 2 g / day, taken at bedtime; vitamin D 4000 U / day; 2. sex hormones estrogen is the drug of choice for the prevention of postmenopausal osteoporosis, testosterone propionate 3. calcitonin 4. painkillers 3. prevention of fracture