Patient: emaciated, easily fatigued; onset more than 10 years ago Laboratory tests, physical examination in August 2008 Total bilirubin 29.9; indirect bilirubin 25.8; ALT 128; AST 40.9 HBsAg +200.21; HBsAb -1.620; HBeAg – 0.002 HBeAb + 11.61; HBcAb +14.91 Ultrasound suggests hepatic parenchymal echogenicity, multiple small intrahepatic hemangiomas (4 1-2 cm). Hepatic penetration Microscopically: 1 hepatic penetration tissue, 1.5 cm long, more disorganized hepatic lobules, 5 central veins, turbid hepatocytes (++), hydropic degeneration (++), punctate/focal necrosis (+), debris-like necrosis (+), a few hepatocytes showing mild atypical hyperplasia; 6 confluent areas, enlarged (++), fibrous tissue hyperplasia (++), lymphocyte and monocyte infiltration (++). The liver was inflamed with G3 grade, fibrosis stage S2. 10 injections of alpha-2b interferon and 3 injections of gamma interferon were used, but there were strong reactions; leukopenia, elevated transaminases, fever, aches and pains, etc. The myocardial injection was stopped, and the oral diazepam tablets were taken; the infusion was continued, and the liver function was basically normal. Can I do it without interferon? What treatment plan should be taken? Li Dongliang, Department of Hepatobiliary Medicine, Fuzhou General Hospital, Nanjing Military Region Li Dongliang, Department of Hepatobiliary Medicine, Fuzhou General Hospital, Nanjing Military Region: Atypical hyperplasia is an abnormal proliferation of epithelial cells due to long-term chronic inflammatory stimulation, also known as heterogeneous hyperplasia and interstitial lesions. According to the degree of heterogeneous proliferation can be divided into 3 grades. The first of these is the “Atypical Hyperplasia”, which is a stage in the formation of malignant tumors and should be taken seriously but without tension. The majority of mild to moderate atypical hyperplasia can be restored to normal, but only some patients with severe atypical hyperplasia will develop into cancer. Your liver histopathology report only shows a few hepatocytes with atypical hyperplasia, which of course is mild atypical hyperplasia and does not lead to liver cancer. Therefore, you should not be too nervous. So, how should you treat atypical hepatocellular hyperplasia? I think the most important thing is that anti-hepatitis B virus treatment “remove” the cause of chronic liver cell damage – HBV, is the best way to improve liver histology, I do not know what your HBV DNA load is, even if the serum HBV DNA is not detected, it does not mean that there is no virus in the liver, your liver biopsy indicates that the liver has obvious active inflammation and fibrotic changes, anti-viral treatment is It is particularly important. If you cannot tolerate interferon (serious adverse effects), you can take oral nucleoside (acid) analogs. In short, anti-hepatitis B virus treatment is the best way to prevent chronic hepatitis from developing into cirrhosis, liver cancer and liver failure.