With the widespread use of nucleoside anti-hepatitis B virus drugs, more and more patients are inquiring about the contradiction between taking medication and having children, which we will share below. Whether the man or the woman is on antiviral treatment, it is not possible to have children, which is clearly stated in the instructions of the drug. In fact, any drug that has not been tested for teratogenicity cannot negate the teratogenic effect on germ cells and embryos, and it is not suitable for a woman to get pregnant during the medication, nor for a man to make his wife pregnant. Do you know why you should not have children, male and female patients of childbearing age? Zheng Ling, Department of Infectious Diseases, Mengchao Hepatobiliary Hospital, Fujian Medical University Why is it also unsuitable for the wife to get pregnant during the period when the man is taking nucleoside analogues? The drugs can cause abnormal development of germ cells and embryonic tissues, and the child will be found to have malformations after birth, such as congenital dementia, congenital heart disease, or deafness or blindness. There is more than one cause of malformations in newborns, and improper use of medication is an important one. The use of certain drugs has the potential to cause malformations while the embryo is in the mother’s body, especially in the early stages when the tissues and organs are not yet fully developed. Nucleoside analogues can induce sperm cell abnormalities, and the embryo is developed from a fertilized egg, and the newborn has half of the father’s genes, can the newborn malformation be unrelated to the father? Can nucleoside analogs definitely cause malformation? The results of animal teratology tests on nucleoside analogs for the treatment of chronic hepatitis B. In order of safety, telbivudine (Subivir) and tenofovir are class B (not teratogenic to the development of animal embryos), while the rest of the nucleoside analogs are class C. No clinical trials have been done, and it is not clear whether they are teratogenic in humans. Herceptin can also treat AIDS, and no malformation has been found in the children of mothers treated with herceptin in Africa, so it is inferred that it is safe to take herceptin at least at the end of pregnancy. Nowadays, in some hospitals in China, mothers with serum HBV DNA levels above the 6th power are given either telbivudine or heprotinin from 28 weeks of pregnancy to delivery, and there is no difference in the malformation rate of newborns born over several years with babies born to normal mothers. Some suggest that women of childbearing age who are chronic carriers of “major triple yang” can also become pregnant and breastfeed, and that blocking therapy is now very well established. It is important to get out of the misunderstanding and not to delay yourself. If you have chronic hepatitis B, you can use liver-protecting and enzyme-lowering drugs to make your condition go into remission, and then have a baby under your doctor’s supervision, if you are sure that your condition is not serious (as judged by your doctor, not just based on the elevated serum transaminases). Anti-viral treatment for hepatitis B is a long-term process. Before starting anti-viral treatment, men and women of childbearing age should ask their doctors about the characteristics of the drugs and make a general plan after discussing with their families. Please make a well thought out decision so that you do not get stuck after starting treatment. Patients who are on antiviral therapy should be careful not to neglect and have an unplanned pregnancy. Patients who are not aware of nucleoside analogs or who are already on treatment should not take the risk of stopping the medication, but should consult their doctor before making a decision, as stopping the medication at will may lead to a relapse of the disease and also prevent them from having children. It is not too late to have children after 30 years old, the more developed the society is, the more the age of childbirth is postponed.