When we talk about gout, we have to talk about hyperuricemia. You may not be a stranger to gout, but I believe that many people do not know much about hyperuricemia. What is the relationship between hyperuricemia and gout, and what is the difference? So today we will focus on the relationship between them and the difference. Hyperuricemia is a group of diseases in which purine metabolism is disturbed and/or uric acid excretion is impaired, resulting in an increase in blood uric acid. Specifically, it refers to a serum uric acid level of more than 420 μmol/L (7.0 mg/dl) in men and 360 μmol/L (6.0 mg/dl) in women at 37°C. This concentration is the saturation concentration of uric acid in the blood, above which urate can be deposited in the tissues, causing histological changes in gout. Gout is a persistent, significant hyperuricemia in which tiny crystals of sodium urate monohydrate precipitate under the influence of multiple factors and are deposited in joints, around joints, under the skin, and in the kidneys, triggering acute and chronic inflammation and tissue damage, with clinical signs and symptoms. The above is the relationship between hyperuricemia and gout, let’s explain the difference between hyperuricemia and gout: a. Gout patients often show intermittent characteristics of blood uric acid, that is, sometimes the blood uric acid is elevated, and sometimes it is normal. Therefore, when a gout patient’s blood uric acid is normal in one test, it cannot be assumed that he does not have hyperuricemia. There should be no difference between hyperuricemia and gout in essence, and they can be regarded as two different stages in the development of a disease. Second, there is no strict boundary between hyperuricemia and clinical gout, so it is difficult to make an exact time judgment on when a patient with hyperuricemia can evolve into gout, and it is impossible to predict whether a patient with hyperuricemia will evolve into gout in the future. In conclusion, hyperuricemia is a prerequisite for gout disease, and without hyperuricemia there is no gout. However, hyperuricemia can exist alone for a longer period of time, even without developing gout. Simply put, hyperuricemia is an increased level of uric acid in the blood, while gout is the presence of redness, swelling, heat and pain in the joints.