Pneumoconiosis is a systemic disease caused by long-term inhalation of productive dust in activities such as mining, metal smelting, mechanical casting, construction industry, jade processing, and tunneling, resulting in fibrosis of lung tissue. Patients with silicosis have no obvious symptoms in the early stages. The most commonly felt is shortness of breath, which occurs early on only during heavy physical labor and is therefore often ignored by workers. Chest pain and chest tightness are also the first to be felt, usually more pronounced on rainy days, after labor or when coughing violently, often as a vague, dull, distending or stabbing pain that can be tolerated. When it gets worse, shortness of breath occurs even during general labor or even at rest, and in severe cases, breathing difficulty is felt even at rest, even when the patient cannot lie down. In early stages of silicosis, there is a mild dry cough, but in advanced stages or with complications (especially lung infections), there is sputum production, increased cough, and blood in the sputum. Late stage patients are often prone to combined pulmonary tuberculosis, lung infection, pulmonary alveoli, emphysema and other lesions, and affect respiratory function, loss of work capacity, requiring years of bed rest, injection and infusion therapy, and even oxygen to maintain life, and eventually complicate respiratory failure or heart failure and endanger the lives of patients, causing a heavy economic burden and a heavy blow to society and families. Although pulmonary fibrosis is irreversible, early treatment can stop the development of the disease, protect lung function, maintain work capacity and improve the quality of life. Large volume whole lung lavage is currently the safest and most effective method for the treatment of pneumoconiosis. Since 1991, China Coal Miners’ Beidaihe Sanatorium has been treating pneumoconiosis and other lung diseases with high volume lung lavage, and has completed nearly 10,000 cases of lung lavage treatment, which is safe and effective. Large volume lung lavage is a treatment for pneumoconiosis patients with persistent dusty and macrophagic alveolitis, which not only removes dust, dust swallowing macrophages and inflammatory and fibrogenic factors from the alveoli, but also removes dust and dust swallowing macrophages not yet encapsulated in the interstitial space of the lung, thus improving symptoms, lung function, quality of life, and stopping or delaying the progression of the disease, which is a kind of etiological therapy. It is an etiologic therapy that cannot be replaced by other methods. Although large volume lung lavage cannot reverse pulmonary fibrosis, it can stop or delay the progression of pneumoconiosis and protect the patient’s lung function because it removes a large amount of dust and dust swallowing macrophages and eliminates the pneumoconiosis factor. Therefore, the earlier the treatment, the better the results. After lung lavage, the patient’s chest tightness, shortness of breath, chest pain, cough and sputum could be significantly improved. 10-year long term follow-up observed that the patient’s physical strength increased significantly, the number of colds and upper respiratory tract infections decreased significantly, lung function improved and the progression of X-ray chest radiograph slowed down significantly, suggesting that large volume lung lavage has a better effect on delaying the escalation of pneumoconiosis, protecting the patient’s lung function, maintaining his work capacity and improving his quality of life.