The targeted drugs currently used in China for the treatment of lung cancer are Iressa (generic name Gefitinib, Gefitinib) produced by AstraZeneca in the UK and Tarceva (generic name Erlotinib, Erlotinib) produced by Roche, both of which belong to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). TKI), both of which have similar uses and efficacy, are used to treat non-small cell lung cancer, especially in people with EGFR mutations (adenocarcinoma, women, non-smoking patients), and can achieve better results than chemotherapy with much weaker side effects. It is also suitable for patients who are not physically able to tolerate chemotherapy. The efficacy of the drug is usually judged by clinical response after a 4-week trial period. Compared with chemotherapy, targeted therapy has a longer period and is more expensive (drug purchase cost about 500 RMB/day), which is not affordable for everyone. Min Li, Department of Respiratory Medicine, Xiangya Hospital, Central South University Therefore, for patients with non-small cell lung cancer, if you consider using targeted drugs, please refer to the following recommendations: 1. Do genetic mutation testing as soon as possible to determine whether you have the conditions for drug use. The time period for mutation testing is short (less than 1 week before and after, including the process of shipping samples) and the cost is much lower than the cost of trial drugs, so it can save time and expense. 2. Differences in the content of discriminatory mutation testing. The mutation testing currently used to know the two drugs, ERSA and Troche, should include exons 18, 19 and 21 of EGFR and exons 12 and 13 of KRAS. When choosing a testing service, you should ask which loci are tested. 3. About the use of targeted drugs. It is not recommended to stop the use of Erythroxa and Troche once they are started. Once the drug is resistant, the drug should be stopped and the treatment plan should be adjusted in time. In addition, these targeted drugs can bring rash, diarrhea, nausea, vomiting, indigestion, constipation and other discomforts. Therefore, patients are advised to take the drugs one hour before or two hours after eating, especially avoid drinking water during or one hour after meals, and eat some bananas, potatoes, and rice to slow down the speed of food passing through the gastrointestinal tract and reduce discomfort.4. About the price of targeted drugs. The price of these two drugs is expensive (about 15000/month if purchased through normal channels), which to a certain extent limits the promotion of their application. The China Charity Federation cooperates with the manufacturer to provide free drugs for the use of ERSA and Troche (see the official website of the China Charity Federation for details); in addition, there are informal channels of “Indian version” of ERSA in the market, the price is much lower than the genuine product, these are “parallel imports” from India into the country. “In principle, there is no difference between the composition, content and effectiveness of genuine ERSA, but some unscrupulous traders will sell fake or adulterated “Indian ERSA”, resulting in a mixed market, so it is not recommended to trust this channel for life and death matters. For more information about China Charity Federation’s free drug giveaway, please refer to: http://www.chinacharity.cn/csxm/yiruisha.aspx/http://www.chinacharity.cn/csxm/abc.aspx/