Why did the doctor prescribe me “anti-inflammatory pain”? Is there a mistake? In the treatment of patients with infertility, we often use a drug called “anti-inflammatory pain”, also known as “indomethacin”. Patients often ask if there is a mistake when they get the medicine. The actual indomethacin is a non-steroidal anti-inflammatory drug that is a prostaglandin synthase inhibitor. The pharmacological action is through the body prostaglandin (PG) synthesis and produce antipyretic analgesic and anti-inflammatory effect. It is mainly used for the treatment of acute and chronic rheumatoid arthritis, gouty arthritis and cancer pain. However, indomethacin can also increase blood folliculopoietin, luteinizing hormone and seminal plasma cAMP concentration. Another thing we must know is that spermatogenesis has a strong relationship with folliculopoietin (FSH) and luteinizing hormone (LH). Luteinizing hormone (LH) promotes the secretion of testosterone by the interstitial cells in the testes. Folliculopoietin (FSH) and testosterone (T) are essential for the initiation and maintenance of the spermatogenic process and the promotion of sperm maturation. Also increased seminal plasma cAMP improves sperm motility and increases the speed of sperm movement. Therefore, clinically, doctors often use this drug to treat male infertility. If your doctor prescribes this medication to you, feel free to use it.