The pregnancy rate of couples with normal fertility is usually about 25~30% in a single month, 75% in six months, and 85~90% in one year.WHO recommends that when a person fails to have children after having regular sexual intercourse for more than one year without using any contraception, there may be a problem with fertility, and a hospital consultation is needed. There are many causes of male infertility, in common order, including idiopathic infertility, varicocele, reproductive tract infections, obstruction of the reproductive ducts, chromosomal or genetic abnormalities, cryptorchidism, immune infertility, endocrine system disorders, dysfunctions of sexual intercourse or ejaculation, testicular tumors, and systemic disorders, etc. Sometimes it is difficult to find the exact cause of the disease. Diagnosis generally starts from three aspects 1. Firstly, ask for a detailed and complete medical history Are there any congenital genetic diseases, parents’ reproductive history and siblings’ reproductive situation. There is no delayed puberty or precocious puberty. The body has no ejaculation disorder or erectile dysfunction, there is no high temperature environment and ray exposure. 2, genital examination, including the distribution of pubic hair, the penis with or without deformity, length and size, with or without prepuce, the size of testicles and epididymis, texture, with or without swelling, as well as the vas deferens with or without defects, varicose veins of the spermatic cord. 3, commonly used auxiliary examination (1) semen routine: to understand the density and vitality of sperm and morphology, if necessary, check the seminal plasma biochemistry, such as seminal plasma zinc, neutral α-glucosidase, seminal plasma elastic scleroproteinase, sperm acrosomal enzyme activity, spermatid maturity, anti-sperm antibodies, and so on. (2) Gonococcus, mycoplasma, chlamydia, prostate fluid routine: to rule out reproductive tract infection factors. (3) Sex hormone: to know whether there is any abnormality in hypothalamic-pituitary-gonadal axis. (4) Scrotal ultrasound: to know the size and blood flow of testicles, the presence of vas deferens, the presence of varicocele and other abnormalities. (5) Transrectal color ultrasound of seminal vesicle glands, ejaculatory ducts, vas deferens, and prostate gland: It is necessary to examine when obstructive azoospermia or dysplasia is suspected. (6) Inhibin B: to understand the spermatogenic function of testis. (7) Chromosomes: including peripheral blood chromosome karyotype and Y chromosome microdeletion, to exclude genetic factors for azoospermia or severe oligozoospermia. Remember: the examination must go to the male department of the regular hospital, do not trust private hospitals and the so-called folk remedies, otherwise it will delay the condition and loss of money! Treatment of infertility three months for a course of treatment Because the testes to make sperm need 1 process, generally from spermatogonia evolve into sperm about 74 days, sperm from the testes and then after the discharge of the epididymis after the maturation process of about 18 days, can be discharged out of the body. Therefore, even if the medication is effective, it will take 3 months before the effects become apparent. Therefore, the treatment of infertility often takes 3 months as a course of treatment, and frequent changes in medication are detrimental to the treatment.