In the daily clinic work, often encountered after years of marriage infertility of young couples, with a thick checklist, routine semen analysis of the list of a sperm can not be found, centrifugation can not be found, and from time to time to see no centrifugation of the laboratory. This is medically known as azoospermia in male infertility, it is usually divided into obstructive azoospermia and non-obstructive azoospermia, regardless of which case the patient belongs to, to achieve natural fertilization, is by no means easy, and non-infarcted situation is even worse. Here I mainly want to talk about some personal feelings in the treatment of patients with non-obstructive azoospermia. For these patients, in the process of initial diagnosis, first of all, we should understand the patient’s medical history, whether he has had other diseases that affect fertility, the next most important step is to give the patient a physical examination, to understand the size of the testicles, the vas deferens and spermatic cord, in general, the larger the volume of the spermatogenesis, the better, and vice versa, the poorer. The next step is to perform semen tests, including seminal plasma biochemistry and blood tests for endocrinology, and chromosomal tests if necessary. In this part of the patient there are some testicular volume between 6-12ml, follicle stimulating hormone (FSH) in the upper limit of the normal value or a little beyond the normal value of azoospermia patients, we in the treatment process routinely apply estrogen receptor antagonist with other drugs, the patient after 1-3 months of treatment will generally produce a very small amount of sperm. It is this very small amount of sperm that can bring hope to young couples, and through intracytoplasmic sperm injection (ICSI) it is possible to bring joy to infertile couples.