Before the terminal stage of liver cancer patients, many serious clinical symptoms and signs will appear, the common ones are as follows: 1. severe abdominal pain caused by huge liver tumor; 2. severe abdominal distension and severe anemia caused by bloody ascites; 3. severe jaundice caused by severe liver dysfunction; 4. oliguria and anuria caused by hepatorenal syndrome; 5. mania followed by coma caused by hepatic encephalopathy. When the above clinical symptoms appear, it indicates that the patient with advanced liver cancer enters the terminal state. Clinicians should communicate with the patient’s family in time to make the patient’s family prepare psychologically.