In patients with gallstones, nausea and vomiting are induced during the acute attack period. Therefore, patients with gallbladder stones and biliary colic should be diagnosed differently from gastrointestinal diseases. Patients with gastrointestinal diseases, such as atrophic gastritis or gastric ulcer, as well as duodenal ulcer and duodenitis, may also exhibit distension and discomfort in the right upper abdomen similar to that of the gallbladder. In addition to ultrasound examination of the upper abdomen, patients with black stool or long-term nausea or vomiting should actively check ultrasound and gastroscopy of the upper abdomen and CT examination of the upper abdomen if necessary. Generally through gastroscopy, inflammation and ulcers in the stomach and duodenum can be detected. For ulcers in the stomach and duodenum, patients need to actively consider taking medication for further treatment. Patients should also have a carbon 14 breath test if necessary to see if they are positive for H. pylori. If H. pylori is positive, anti-H. pylori treatment should be actively considered. In addition, for patients with gallstones, laparoscopic cholecystectomy should be actively considered if they have symptoms of right upper abdominal pain, a family history of tumor, and underlying disease problems.