Reply: The main treatment of multiple bone metastases is systemic treatment combined with local radiotherapy. Systemic treatment includes chemotherapy, targeted therapy and treatment with bisphosphonates for bone protection. Bone protective bisphosphonates should be routinely used, and now the more commonly used ones are zolay phosphate and pamiphosphate. Radiotherapy is more reliable for local pain relief, with little side effects, and can be considered for obvious local pain. Targeted therapy can provide better control for some suitable patients, and chemotherapy should be considered if it has not been used before and can be tolerated by the body. For patients with particularly extensive bone metastases and widespread pain, systemic nuclear therapy can also be considered. In addition, local particle therapy, nerve block therapy and other palliative pain management measures are also available in special cases.