The principles of treatment and medication for neurogenic syphilis are the same as for other types of syphilis. In principle, early detection and early treatment are required, and the earlier the treatment, the better the prognosis. If neurosyphilis is diagnosed, treatment should be carried out in a timely manner. Penicillin is the drug of choice for all types of syphilis, and the drug of choice for neurogenic syphilis is also penicillin. First, use short-acting penicillin G for 10-14 days continuously, then switch to long-acting benzathine penicillin once a week for 3 times. If you are allergic to penicillin, you can use ceftriaxone sodium instead. Tetracycline and erythromycin can also be used, but they are less effective than penicillin. It should be emphasized that patients with neurogenic syphilis should be hospitalized and oral prednisone should be given in order to avoid the Jihai reaction. The so-called Jihai reaction is that patients with neurosyphilis, after receiving highly effective anti-syphilis spirochete drugs, the syphilis spirochete is rapidly killed and a large amount of allogeneic protein is released, causing an acute hypersensitivity reaction in the body, manifested as chills, fever, headache, rapid breathing, tachycardia, general discomfort and aggravation of the primary disease.