1, to truthfully tell the dermatologist about the disease, in order to timely diagnosis and treatment, do not make up your own medical history. 2. Sexual intercourse should be prohibited during the treatment period to avoid infecting each other. Once the diagnosis is confirmed, those who have sexual contact with them should also be examined at the same time. 3, follow the doctor’s instructions on the use of drugs, do not indiscriminately seek medical advice, indiscriminate use of drugs. Before injecting penicillin, skin test should be done to know if there is any allergic reaction. After the injection, a large number of syphilis spirochetes will be killed and the patient will absorb a large amount of heterogeneous proteins and endotoxin, and some patients with early syphilis will have systemic reactions such as high fever, headache and even jaundice within 24 hours. Late syphilis this reaction is less, once it happens, the consequences are serious. So never inject penicillin on your own. 4, adhere to the regular treatment. Because of the slow progress of syphilis, there are no obvious conscious symptoms, often mistakenly considered cured and interrupted treatment. However, at this time is the disease in latent, not only will soon relapse, but also may continue to infect others. 5, regular medical checkups. Usually after treatment, the symptoms disappear quickly, and the titer should be reduced at least 4 times in 6 months after treatment. The decrease will be slower for those who have been ill for a long time. Otherwise, it is recommended to check HIV and cerebrospinal fluid. If the results are not abnormal, it is recommended to give benzathine penicillin 2.4 million units once a week for 3 weeks. It is not called a cure until the serologic reaction turns negative (advanced syphilis is more difficult to turn negative). Observation should be continued for 3 years. In the first year, check every 3 months; in the second year, check every 6 months; in the third year, final check. If necessary, annual check-ups.