The patient: In the beginning of 2012, there was a hard chancre. At that time, the syphilis test in Shanghai Putuo Central Hospital was negative, and later, the syphilis was not detected by Changning CDC and Huashan Hospital, and was treated as glansitis. He was diagnosed with syphilis at Shanghai Dermatology Hospital in June 12, with RPR 1:32, and started treatment in July with three injections of benzathine penicillin and three weeks of intramuscular injection. Tested twice at Changning CDC between Oct’12 and May’13, both told normal. 1. Is it still infectious? Can I have sex with a condom? Can I have oral sex or kiss without a condom? 2. What is the meaning of the titer results in Dec. 12 and May 13 respectively. 3. What is the difference between the test results of Changning CDC and Shanghai Dermatology Hospital? What are the indicators checked? Huaian Second People’s Hospital Dermatology Department Zhou Wujun: RPR is used to observe syphilis disease activity. It is generally believed that a titer greater than 1:8 indicates disease activity, so the difference in significance between 1:1 and negative is not significant and sometimes related to the judgment of the tester. You are not infectious now. You can live normally, but you need to prevent reinfection and the possibility of recurrence, so you also need to be reviewed regularly. Patient: Director Zhou, I would also like to ask, does a RPR test result of + mean a titer of 1:1 (that’s what my treating doctor explained), and what does +/- mean? Huaian Second People’s Hospital Dermatology Department Zhou Wujun: 1:1 means positive, and + means the same thing. +, – means suspicious positive. The patient: I mean the RPR test result is + does it mean the titer is 1:1. please reply to director Zhou, thank you. Huaian Second People’s Hospital Dermatology Department Zhou Wujun: Positive includes a range of situations from 1:1 to 1:128, so after the positive, you have to look at the titer.