Syphilis is a chronic systemic sexually transmitted disease caused by the syphilis spirochete and is mainly transmitted through sexual contact. According to the time of infection can be divided into two categories: congenital syphilis and acquired syphilis, the main symptoms are as follows: I. Congenital syphilis: usually caused by the transmission of the virus from the pathogen in the mother to the fetus through the placenta. 1. Early congenital syphilis: the child is born thin, 3 weeks after birth, symptoms appear, swollen lymph nodes all over the body, no adhesions, painless, hard to the touch, more syphilitic rhinitis. Skin lesions appear about 6 weeks after birth as blisters, maculopapular lesions (syphilitic aspergillosis) or macules, papules, and scaly lesions. The child may develop osteochondritis, periostitis, mostly hepatosplenomegaly, thrombocytopenia and anemia, neurosyphilis may occur, but not sclerosing; 2. Late congenital syphilis: occurs after the child is 2 years old, one type is permanent damage to bone, teeth, eyes, nerves and skin due to early lesions, such as saddle nose, without activity. The other category is the clinical manifestations due to active damage, such as keratitis, neurological deafness, hepatosplenomegaly, joint effusion, periostitis, dactylitis and skin mucosal damage, etc.; 3. Congenital latent syphilis: fetal syphilis without clinical symptoms and positive syphilis seropositivity. The main clinical symptoms are hard chancre and sclerosing lymphadenitis. The main clinical symptoms are hard chancre and sclerosing lymphadenitis. The hard chancre is a single, painless, round or oval, well-defined ulcer, higher than the skin surface, with a cleaner sore surface, more secretions in those with secondary infection, cartilage-like hardness when touched, lasting for 4-6 weeks, and can heal on its own. The patient can have enlarged lymph nodes in the groin or nearby in 1-2 weeks after the appearance of hard chancre, which can be single or multiple, and the enlarged lymph nodes are of different sizes, hard, non-adhesive, non-ruptured and painless. The second stage of syphilis is often manifested as a rash, the main rash type are spot-like, papule-like, pustular, as well as flat warts, palmoplantar syphilis rash. About 50% of patients show mucosal damage, syphilitic alopecia, bone and joint damage, ocular syphilis, neurosyphilis, and generalized superficial lymph node enlargement, etc.; 3. Stage III syphilis: that is, the advanced stage, there is devastation. Severe vascular, cardiac, and mental problems often occur at this stage, and in severe cases, death may even occur. If the patient develops a rash and actively cooperates with the doctor for relevant treatment, it is not easy to develop into stage III syphilis; 4. Acquired latent syphilis: positive syphilis serological test and normal cerebrospinal fluid examination, currently without any clinical signs and symptoms of syphilis. Syphilis is highly contagious, so patients are advised to actively undergo examination and treatment, and should pay attention to the prohibition of intercourse during treatment.