With the liberalization of the two-child policy, many families are facing the problem of having children. Many women with syphilis also have plans to become mothers. So, is it possible to get pregnant with syphilis? What do you need to do to prepare? A. Patients who have been infected with syphilis can consider having children as long as they have undergone regular treatment and the RPR index has turned negative or has not turned negative but has maintained a low titer for a long time. Syphilis infection should receive regular treatment and regular follow-up after regular treatment, that is, every three months for the first year after treatment, and every six months for two years after one year. Second, if pregnancy is planned, a non-syphilis spirochete antibody serologic test (RPR or TRUST) should be done at least 1 month before pregnancy to compare with previous results. If the non-syphilis spirochete antibody serologic test changes from negative to positive, or if the titer increases by more than 2 dilutions (e.g., from 1:2 to 1:8) (both of which are considered serologic relapses), or if there is a recurrence of clinical symptoms, treatment should be repeated or the treatment course should be extended (2 courses of treatment with a 2-week interval). Third, there are very few patients will appear after the regular anti-syphilis treatment, non-syphilis spirochete antibody titer down to a certain level that no longer fall phenomenon, and long-term maintenance of this state, we call “serological fixation”. However, it should be noted that in this case, the titer of non-syphilis spirochete antibodies does not exceed 1:8, which may be caused by incomplete medication or irregular treatment, and may be followed by a course of treatment and, if necessary, testing of the cerebrospinal fluid, cardiovascular system, and HIV antibodies. If all these are negative and after regular treatment, even if the non-syphilis spirochetes are not negative, the above-mentioned patients can prepare for pregnancy. If the RPR is negative during pregnancy, no treatment is needed. If the RPR is positive, it is better to repeat the treatment, and two courses of long-acting penicillin treatment can be given during the first and second trimester of pregnancy, that is, during the period of 0-3 months and during the period of 7-10 months, for three weeks each time, with one long-acting penicillin injection per week. V. Whether or not formal anti-syphilis treatment is given, in principle, monthly testing for TRUST or RPR is recommended during pregnancy; VI. On the day of birth, cord blood is drawn for the child to be tested for syphilis.