There are many diseases that cause high uric acid, such as inborn metabolic diseases, chronic kidney lesions, blood diseases and tumors. In addition, high uric acid may also be due to physiological factors and drug factors. 1. Inborn metabolic diseases: Glycogen accumulation disease can cause high uric acid, which belongs to hereditary disease, is an inborn metabolic disorder caused by enzyme defects, and is usually autosomal recessive. 2. Chronic kidney disease: chronic glomerulonephritis, pyelonephritis and other diseases, can lead to a decrease in glomerular filtration rate, resulting in a decrease in the amount of excretion of uric acid, and therefore will cause high uric acid. 3. Blood diseases and tumors: multiple myeloma, leukemia, hemolytic anemia, malignant tumors and tumors after radiotherapy may lead to a large amount of their own nucleic acid decomposition, which can be accompanied by high uric acid. In addition, high uric acid may be related to physiological factors in addition to diseases, such as the intake of many high-purine foods, which may also cause high uric acid; some drugs may also cause high uric acid, such as insulin, furosemide, high-dose vitamin C, small-dose aspirin and so on. There are many diseases that cause high uric acid, and high uric acid may also be caused by other reasons, it is recommended that patients seek timely medical attention to identify the causes, and treatment under the guidance of a professional doctor.