Acne, commonly known as “acne” or “pimples”, is a common dermatological condition caused by chronic inflammation of the sebaceous glands of hair follicles. The causes of acne are complex. Environmental pollution, dietary habits, and irregular sleep patterns can also lead to acne, but most of the more stubborn acne is often related to endocrine disorders, and for women, it is often closely related to their menstrual disorders. PCOS is an endocrine-metabolic disorder in which the level of androgens in the patient’s blood is significantly elevated, and the cortical glands are stimulated by androgens to secrete too much sebum, which is not excreted and collects in the hair follicles. Acne caused by PCOS is different from acne vulgaris in that the symptoms are stubborn and the treatment is difficult, and the results of various treatments are not ideal. In contrast, acupuncture treatment is a good option, which is not only safe without side effects, but also economical and effective. Acupuncture can promote local qi and blood flow, move qi and blood, and accelerate the absorption of inflammation. More importantly, acupuncture treatment can regulate endocrine disorders and regularize menstruation by selecting acupuncture points according to the evidence.