I. Precautions for the use of Pulcolcimol (FK506) 1. Note before using Pulcolcimol: whether you are pregnant or preparing to become pregnant; whether you are breastfeeding; whether you are allergic to Pulcolcimol and adjuvant components. 2, dietary attention: eating can affect the absorption of the drug, there are certain fatty foods can reduce the absorption of the drug, it is recommended to take it orally under an empty stomach, one hour before or 2-3 hours after meals, drinking alcohol while taking Pulcolcolax can increase visual and neurological adverse reactions. 3. Patients should not change the dose of Pulcolax or discontinue the drug by themselves; any adjustment of the dose should be made by your transplant doctor. 4. Common side effects and treatment: side effects are often tremor, headache, insomnia, blurred vision, cataracts, nausea, hyperglycemia, etc. Contact your doctor immediately when side effects occur. They are usually related to high concentrations and most occur within one month of taking the drug. Generally, the side effects will be relieved or disappear when the drug is reduced or the concentration is lowered. Second, the application of drugs after liver transplantation should be very scientific, some drugs will increase the blood concentration of immunosuppressants, while some drugs will decrease the blood concentration of immunosuppressants, and some other drugs are inherently nephrotoxic and should be avoided. 1.The drugs that may increase the blood concentration of immunosuppressants are: erythromycin, coxarubicin, ketoconazole, tenelheart, verapamil, gastrofacial, oral contraceptives, methyltestosterone, etc. 2.Drugs that may reduce the blood concentration of immunosuppressants include: phenobarbital, phenytoin sodium, dipropyl acetate, rifampin, isoniazid, etc. 3. Drugs that should be avoided include: gentamicin, kanamycin, neomycin, polymyxin, furantadine, vancomycin, etc. Third, the importance of taking medication on time The transplanted liver, as a foreign object, is always under the surveillance of the recipient’s immune system. Once the immunosuppressive effect is weakened, the body’s immune system will attack the transplanted liver, that is, the rejection reaction. Sometimes this rejection is very weak and there may be no clinical symptoms, but damage to the liver has already occurred. Therefore, it is very important to take the medication on time and as prescribed, so that the immune mechanism of the body is in a stable immune transplantation state to reduce the incidence of rejection and prolong the survival period of the transplanted liver. Fourth, the importance of blood drug concentration detection in immunosuppressive therapy, the drug concentration in the patient’s body must reach a stable concentration to achieve its therapeutic effect. The gap between the effective therapeutic concentration and toxic concentration of various immunosuppressive drugs is very small, and the absorption and metabolism of drugs vary greatly among different individuals, therefore, regular detection of blood drug concentration is needed to achieve both therapeutic effects and prevent drug toxicity. Fifth, the importance of regular and regular follow-up visits Shortly after surgery, with the recovery of liver function, all aspects of the body will undergo great changes, the improvement of liver function, appetite and nutritional status, weight will increase, weight changes, the dose of immunosuppressive drugs will need to make certain adjustments. The recovery of liver function will also lead to some improvement in hypertension and heart disease, all of which will require your doctor to make adjustments to your treatment plan. After liver transplantation, the condition gradually stabilizes and the dose of medication has to be adjusted, which is quite complicated and must be done by the transplant surgeon according to the condition combined with the blood concentration. Therefore, after liver transplantation, patients must have regular and periodic follow-up visits.