Recently irritability can be treated clinically with psychotherapy, medication and physical therapy. Irritability itself is an expression of emotion, and research through cognitive-behavioral theory shows that mood can be adjusted by improving the patient’s thoughts. Because thoughts determine emotions and emotions in turn reinforce thoughts, cognitive reconstruction and improvement of irritability can be achieved by correcting the perception of irrational thoughts. In addition, if irritability reaches the state of disease, systematic application of medication is needed, such as anti-anxiety drugs, antidepressants and antipsychotic drugs have good therapeutic effects for treating irritability caused by schizophrenia, mania, depression, and anxiety disorders. In addition, physical therapy also has a certain therapeutic effect on irritability, such as multi-parameter biofeedback therapy, electroconvulsive therapy and transcranial magnetic stimulation therapy can achieve good therapeutic effects.