After the end of this year’s high school and college entrance exams to see part of the drug is not very sensitive to the patient with more than two years of time mental symptoms gradually recovered, some successfully participate in the high school and college entrance exams, some resume normal work, some married and have children, is very gratifying and emotional. Patient 1, 14 years old onset of childhood schizophrenia, serious self-injurious behavior, in the case of other kinds of treatment is ineffective, with clozapine 800 mg symptoms gradually control, and after three years of speech function and social function gradually recovered, has married and had a smart and lovely pair of children, the daughter has been in elementary school. Patient 2, 18 years old onset of refractory depression, severe retardation and suicidal ideology, life and self-care seriously impaired, in the case of other kinds of treatment is ineffective, with two kinds of antidepressant drug combination of adherence to the treatment for two years, life and work capacity gradually recovered. Patient 3, 17-year-old onset of refractory depression combined with anxiety disorder, severe retardation and suicidal ideation, serious impairment of self-care, in the case of other kinds of treatment is ineffective, with two antidepressants, two emotional stabilizers, an antipsychotic drug combination of adherence to the treatment of one year after the mood to recover 30%, two years after the mood to recover 40%, three years after the mood to recover 80%, has been able to adhere to the university. Patient 4, 18 years old with the onset of bipolar disorder with psychotic symptoms, mood fluctuations, treatment and years after the gradual stabilization of mood, this year has insisted on attending a major university. Patient 5, 16-year-old schizophrenia, severe command hallucinations and self-injurious behavior, in the case of other kinds of treatment is ineffective, with clozapine 600 mg treatment for two years after the gradual dilution of hallucinations, self-injurious behavior disappeared. Patient 6, 22-year-old onset schizophrenia, weight 220 pounds, severe critical hallucinations and relational delusions predominate, Rida 12 mg treatment is ineffective, with olanzapine 40 mg treatment for two years before critical hallucinations and relational delusions gradually disappeared. Poor emotional communication and passive withdrawal took another two years to taper off. Currently in a relationship and working. The textbooks say that a drug is judged to be ineffective when it is ineffective after 4-6 weeks of treatment at full dosage, but some literature states that some drugs take more than two years in some patients. This is true clinically. About 60% of patients with multiple relapses are not as sensitive to antipsychotics as they were the first time. A first episode of a smaller dose of an antipsychotic with fewer side effects will be significantly effective in about a month, and a second relapse may be ineffective with a very large dose of the same antipsychotic used the first time. Even if it is effective, the time for the relapse treatment to be effective will be significantly longer than the first treatment, which may be two months, half a year, one year, or even two years to gradually become effective. The test is the patience of the parents and the determination and skill of the doctor.