Antihypertensive drugs that do not trigger gingival hyperplasia include calcium channel blockers, with representative drugs such as amlodipine, nifedipine, and felodipine. Angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, diuretics, beta-blockers, and other types of antihypertensive drugs do not trigger the appearance of gingival hyperplasia. The representative drugs of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists are Benadryl and Irbesartan, etc. The representative drugs of beta-blockers are Bisoprolol and Propranolol, etc. The representative drugs of diuretics are spironolactone, hydrochlorothiazide, etc. These drugs generally do not occur gingival hyperplasia, but each antihypertensive drug has its own adverse effects, that is, side effects. In the process of application, the actual situation of the patient should be taken into account, taking into account whether the patient has a history of drug allergy or other medical history in addition to hypertension to make a comprehensive consideration and individualized drug regimen selection.