Currently, liver transplantation is considered absolutely unsuitable for: 1. people with uncontrollable infections (including bacterial, fungal and viral infections); 2. people with HIV infection; 3. people with alcohol or drug dependence that is difficult to quit; 4. people with irreversible brain tissue damage; 5. people with malignant tumors outside the liver that are difficult to eradicate; 6. people with psychological disorders or neuropathies that are difficult to control. The following people are also generally not considered for liver transplantation: 1. the recipient is ≥ 65 years old or < 1 year old; 2. there are difficult surgical anatomical conditions; 3. there are progressive malignant tumors of the liver; 4. there are severe heart, lung, kidney and other vital organ pathologies; 5. there is a previous history of psychiatric disease. Of course, this is only relative and clinically needs to be determined according to the individual patient's situation.