In the presence of fever, progressive anemia, significant bleeding tendency or bone and joint pain, etc. these conditions are suspected to be suffering from leukemia, in addition to a few people may also have symptoms such as convulsions, blindness, toothache, pericardial effusion, tetraplegia, etc. 1, fever: is one of the most common symptoms of leukemia, fever is mainly caused by infection, fever causes infection, including stomatitis, pneumonia, perianal abscess, fever It can also be a symptom of acute leukemia itself; 2. Progressive anemia: anemia can appear in the early stage, and patients can show weakness, pallor, palpitations and shortness of breath if they have progressive anemia; 3. Bleeding: bleeding can be bleeding from the mucous membrane in the mouth and superficial parts of the skin, or extensive bleeding from the respiratory tract, digestive tract and other internal organs; 4. Bone and joint pain: bone and periosteum can appear due to leukemic infiltration Bone pain, which can be confined to the joint area, or diffuse pain in the sternum, ribs or back; 5. Lymph node enlargement: Patients have mild to moderate lymph node enlargement on the body surface, or even deep lymph node enlargement, such as mesenteric lymph nodes and peritoneal lymph nodes. All of the above symptoms can help to identify early stage of leukemia, but the diagnosis of leukemia cannot be confirmed simply by clinical manifestations, and bone marrow aspiration and bone marrow section biopsy are required. In addition, in the case of chronic leukemia, there are basically no obvious symptoms in the early stages, and they are mostly detected during physical examinations and other tests.