Why does acne keep growing? Is there a medical treatment that can completely eradicate the causes of acne? What are the best and fastest treatments available? I believe these are the most important topics for every young person suffering from acne. Let’s unravel the mystery of acne development and learn about the most advanced phototherapy technology for acne treatment. The headache of Propionibacterium acnes and the light-sensitive substance porphyrins within Propionibacterium acnes. Along with your growth, puberty creeps up on you, bringing you self-confidence and the worry of “losing face”. Acne is the most prevalent skin disorder on the face during adolescence. When you look in the mirror every morning and see a face full of acne, it is really unpleasant and you can’t help but want to squeeze the annoying and sad acne with your hands. However, squeeze a ten, not good enough to leave a face full of bruises, how to see how like a sieve hole! To get some drugs back to the pharmacy, can temporarily improve, and soon remain as before, only a sigh of relief, alas ~, how my life so bitter? I don’t know, you are not the only one who suffers from the same disease, you are not alone among the many acne sufferers! Medical research on acne has never stopped. Early on, researchers discovered that acne inflammation is caused by an anaerobic bacterium called Propionibacterium acnes, which is insensitive to common antibiotics. Even with sensitive antibiotics due to the special structure of the sebaceous glands, it usually takes more than three months for the treatment to take effect, which is rarely possible for the majority of acne sufferers and cooperation to adhere to the treatment. The bacteria are deep within the sebaceous glands of hair follicles, lurking for a long time and waiting for an opportunity to multiply, making it difficult for people to treat. Second, limited therapeutic drugs The number of effective therapeutic drugs for acne in the formal textbooks is limited. Tetracycline is one of the effective therapeutic drugs recognized by dermatologists at home and abroad. Since the drug cannot reach the sebaceous glands directly, the concentration that can effectively kill the germs through the sebaceous gland cyst wall needs to be taken for a long period of time. Regular treatment takes 3 to 6 months and patient compliance is poor, making clinical treatment difficult. Tetracycline has been delisted from our pharmacopoeia due to more side effects and risks. Although the second-generation tetracycline Minocycline tetracycline has reduced the side effects, due to the high price of taking a long course of treatment, to adhere to the burden of treatment. So doctors began to explore new, fast-killing treatments that can cause acne germs. III. Visible light therapy and the birth of blue light Sunlight is the energy of life, providing energy for all things to grow. Humans have a long history of using light to treat diseases. Different wavelengths of light have different effects on the skin, and the application of light therapy in the treatment of skin diseases is flourishing. The wavelength range of visible light is 760-400nm, and within this wavelength range, different wavelengths produce different colors. Different wavelengths of visible light have unequal photon energy. The circadian rhythm of human and animal activities and a series of physiological function rhythm, and the natural lighting rhythm (day and night alternation) has a close connection, so visible light is extremely important to living organisms. The wavelength is 410-460nm, and it is blue-violet light. Propionibacterium acnes, which is deeply embedded in the sebaceous glands of hair follicles, produces an orange-red light-sensitive substance called porphyrins during its metabolism, the main components of which are fecal porphyrin III and protoporphyrin (PPIX) These porphyrins mainly absorb visible light at 400-415 nm. In vitro studies have shown that irradiating the colonies of Propionibacterium acnes with blue visible light causes photoexcitation of bacterial porphyrins, which stimulates the production of monomorphic oxygen, the latter of which can kill the bacilli. 2000 British doctors used 415nm blue light and 660nm red light to treat acne and achieved satisfactory clinical results, thus inventing the red and blue light therapy instrument. Blue light can kill the acne bacillus, and red light can eliminate inflammation. Blue light is suitable for the treatment of mild to moderate acne because it does not contain ultraviolet light and has no irritating effect on the skin. Blue light effectively kills Propionibacterium acnes IV. Prospects of blue light therapy for acne As blue light therapy belongs to the category of physical therapy, it greatly avoids the danger of using antibiotics. It has been commonly used in the treatment of acne in Europe and developed regions in Asia. Research results show that the effect of one month of blue light treatment is equivalent to the effect of three months of a single oral antibiotic. Since P. acnes lives in the sebaceous glands, a large number of porphyrins, a metabolite of the bacterium, are present in the sebaceous glands, and under blue light irradiation, some of the sebaceous glands are destroyed, resulting in a reduction in oil production and a significant improvement in pore size. Each blue light exposure takes only 15-20 minutes, and the eyes are protected with eye shields during the treatment. Inflammatory acne damage is quickly and visibly reduced after the first session (2 sessions per week for 4 weeks), with no pain, no hyperpigmentation, and no disruption of normal work in any way. About 2 courses of treatment can clear up 70-80% of the inflammation, which can be maintained for a longer period of time after the end of treatment. Blue light treatment is especially suitable for patients with extensive skin damage on the back and chest. Oral or topical application of light-sensitive drugs can enhance the therapeutic efficacy. As the pace of people’s lives accelerates, the demand for speed and efficacy of disease treatment is getting higher and higher. Since blue light treatment does not delay time and has fast results, it is believed that more and more acne patients will be accepted in the near future.