Chronic myeloid leukemia is generally divided into chronic phase, accelerated phase and acute phase: 1. Chronic phase: primitive cells in peripheral blood and bone marrow <10%, without reaching the criteria of accelerated phase and acute phase; 2. If fever, weakness, and weight loss, bone pain, gradual anemia and bleeding appear during the course of the disease, the accelerated phase should be considered, when often the primitive blood cells in peripheral blood and bone marrow can reach 10% to At this time, the peripheral blood and bone marrow primitive blood cells can reach 10% to 10%, peripheral blood basophils reach 20%, and there is persistent thrombocytopenia, or increased, and clonal chromosomal abnormalities during treatment, the patient has an enlarged spleen or increased white blood cells, any point can be classified as the accelerated phase; 3, acute change phase: need to reach the peripheral blood and bone marrow primitive cells exceed 20%, or bone marrow biopsy with leukocyte aggregation, or extramedullary primitive Most of them are transformed into acute granulomatous changes, and a small number of them can be acute lymphoid changes, and a smaller number of patients have megakaryocyte-like lesions. Patients who reach the acute phase have a very poor prognosis and can die within a few months if not treated aggressively at this time.