The quadrivalent cervical cancer vaccine will not affect menstruation. Quadrivalent cervical cancer vaccine, also known as HPV vaccine, mainly prevents HPV16, HPV18, HPV6 and HPV11 infections, and effectively reduces the incidence of HPV infection and cervical cancer in women. At present, there is no scientific evidence to confirm that the quadrivalent cervical cancer vaccine has any effect on menstruation. The main factors affecting menstruation are ovarian endocrine dysfunction caused by excessive weight loss, stress, late night, emotional factors, medication and diseases. It is recommended that it is best to avoid menstruation when taking quadrivalent cervical cancer vaccine, and it is prohibited to take quadrivalent cervical cancer vaccine after pregnancy. If menstruation is delayed and the amount of menstruation is abnormal, it is recommended to check the cause of the disease in hospital. After taking Quadrivalent Cervical Cancer Vaccine, you need to go to the hospital regularly for HPV screening, and if you have any uncomfortable symptoms, you should go to the hospital in time and consult the physician for guidance.