For the treatment of hard fibroids, chemotherapy is a third-line treatment option, meaning that patients are considered for chemotherapy only if they cannot be surgically removed and are not suitable for radiotherapy. The commonly used chemotherapy regimen is: vincristine given intravenously once a week; methotrexate tablets given orally 5 days a week with 2 days off or continuously for one year. The day you start oral methotrexate is the day you start intravenous vincristine. How is the chemotherapy process reviewed? Currently, the recommended duration of chemotherapy treatment for sclerofibrosarcoma is 6-18 months, and it is generally recommended to continue chemotherapy for 1 year. During this 1 year period, the tumor is basically in a stable state for the first 6 months, and the tumor only starts to shrink after 6 months of chemotherapy. Therefore, patients are routinely advised to review MRI after six months of chemotherapy to check the tumor condition. When chemotherapy has been completed for 1 year, MRI will be reviewed again, and thereafter every 6 months. In addition to checking the tumor status, liver injury needs to be closely observed during chemotherapy. Generally speaking, during the first 1-2 months of chemotherapy, blood should be drawn once a week to check liver and kidney function and blood routine; after the dosage of liver-protective drugs and methotrexate is adjusted to a balanced state, that is, when the transaminases can be maintained at a basically normal level, liver function can be rechecked once every 2 weeks thereafter. Patients undergoing chemotherapy for hard fibroids also need to monitor their white blood cells and have their blood checked once a week during the first month of chemotherapy; thereafter, the frequency of blood checks can be reduced as appropriate. What are the precautions related to chemotherapy? 1. For foreign patients who are seen in Beijing, they do not need to stay in Beijing for a long time if they choose to undergo chemotherapy. After 1-2 chemotherapy sessions, if it is determined that there are no acute side effects, you can take the chemotherapy regimen away and return to the local hospital for treatment, but you need to keep in touch with your primary care physician for a long time to facilitate the monitoring of chemotherapy effects; 2. central venous line is needed. There are two options for this central venous line: subclavian or internal jugular line and peripheral line. If a peripheral vein is placed, this tube is buried in the body for no more than six months; a subclavian vein is placed for no more than three months and needs to be replaced in the hospital when it expires; 3. During chemotherapy, try not to eat foods that may contain estrogen, including honey, etc. Some health products whose ingredients are not known are also recommended not to be consumed as much as possible. Other than that, there is no need for special taboos; 4. During chemotherapy and after chemotherapy, it is necessary to avoid trauma when exercising. Because if trauma affects the tumor, it may stimulate the tumor and make the tumor come back with serious consequences. Besides, under the premise of not stimulating the tumor, sports such as running and cycling can be carried out.