The etiology of this disease is unknown and may be related to trauma, pregnancy, surgery, and systemic connective tissue abnormalities. During pregnancy, blood estrogens are elevated, and this, combined with the possibility of abdominal wall injuries during labor, may be the reason why sclerofibroids are more prevalent in adult females, and sclerofibroids are also found as a part of the Gardner syndrome consisting of multiple polyps of the rectum, osteomas, dermatomas and sclerofibroblastomas, which are often associated with a hereditary Family history. Wang Zhimin, Department of Anus and Intestines, Thousand Buddha Mountain Hospital, Shandong Province, China.