History/symptoms: 1. 8 or more otitis media in a year 2. 2 or more severe sinusitis in a year 3. 2 or more pneumonia in a year 4. 2 or more infections of uncommon sites or deep areas 5. Recurrent deep skin or organ infections 6. Infections requiring sedative antibiotics for clearance 7. Unusual or conditional pathogenic infections 8, Family history of primary immunodeficiency 9, Growth arrest 10, Lack of lymph nodes or tonsils 11, Skin lesions: dilated capillaries, bleeding spots 12, Cutaneous mycobacteria, lupus erythematosus-like rash 13, Ataxia (A-T) 14, Thrush after one year of age 15, Oral ulcers