After hormonal treatment, active SLE usually tends to go into remission, and the disease moves into a stable (remission) phase. Since there is no cure, the disease may change from stable to active phase under the influence of certain triggers, such as infection, pregnancy, surgery, fatigue, or discontinuation of medication. From the clinical point of view, patients in remission, if the following symptoms and abnormalities in laboratory tests occur, then we should consider the disease recurrence. 1, unexplained fever: i.e., the fever cannot be explained by colds, pharyngeal, pulmonary, urinary tract infections, etc., and is not caused by other diseases; 2, fresh rash reappears or is accompanied by vasculitis-like rashes at the ends of the fingers (toes) or in other parts of the body; 3, swollen and painful joints reappear; 4, hair loss is obvious; 5, fresh ulcers of the mouth and nose; 6, the appearance of hydrothorax or pericardial effusion; 7, an increase in proteinuria; 8, a significant decrease in white cells or Thrombocytopenia or anemia is obvious; 9, the appearance of neurological symptoms: such as headache, vomiting, convulsions; 10, anti-double-stranded DNA antibody titer increased; 11, blood sedimentation increased rapidly, more than 50 mm / hour; 12, complement decreased, especially C3 decreased. Combined with the history and detailed physical examination, it is generally not difficult to make the judgment of disease recurrence. Complement C3 and anti-double-stranded DNA antibodies are often laboratory indicators of SLE activity. Therefore, in order to detect changes in the disease in time, patients with fever should be examined in the hospital in a timely manner. Doctors require patients to have regular blood tests for the purpose of early detection of changes in the disease. Some of the reasons for relapse are clear, such as sudden discontinuation or rapid reduction of hormones, or overwork, sun exposure and so on. One farmer patient had a lupus flare every year after the summer or fall harvest; some also had a flare during pregnancy or after childbirth. The reasons for the flare-ups are not always clear. It is important to note that other diseases must be excluded in order to have a relapse, and that a positive antinuclear antibody or a non-decreasing antinuclear antibody titer should never be regarded as a relapse, because antinuclear antibodies do not necessarily parallel disease activity. Nor should one simply assume that headaches and vomiting are lupus flares, exacerbations, or a combination of encephalopathies. A patient who had been ill for many years adjusted his hormones on his own without following the doctor’s instructions, adding a few tablets of hormones whenever there was some discomfort. After a headache and vomiting, the patient increased prednisone to 40mg per day on his own. Unknown to him, on the basis of taking hormones and immunosuppressants for a long period of time for several years in a row, his immune function declined and he was prone to combined infections, and he was confirmed to be suffering from cryptococcal meningitis by lumbar puncture of the cerebrospinal fluid, and he was hospitalized for 8 months. Therefore, after the appearance of the above symptoms in a timely manner to seek medical treatment, early and reasonable control can benefit the most.