1, except chronic infection: the clinical manifestations of opportunistic infections can be quite insignificant, but will progress rapidly after hormonal therapy. Check chest X-ray and PPD test. 2.Evaluation of glucose tolerance: checking fasting blood glucose before impact is sufficient, and pay attention to monitoring blood glucose level regularly during hormone application. 3.Evaluation of osteoporosis risk: Bone density examination. Long-term use of hormones should be prophylactic treatment. 4.Evaluation of the risk of gastrointestinal hemorrhage: Stool occult blood and blood routine should be checked before treatment, especially pay attention to the level of MCV. 5.Evaluation of the risk of cardiovascular events: ask whether there are symptoms of chest pain and chest tightness, measure blood pressure and check whether there is peripheral edema before treatment. During the application of hormones, regular review should be conducted. 6. Evaluation of mental consciousness: A simple mental consciousness scale should be carried out for future comparison. This is especially true for patients with a history of abnormal mental status.