Glucocorticoids, such as prednisone, methylprednisolone, dexamethasone, and so on, are commonly used clinically in patients with nephrotic syndrome. The classic mechanisms by which glucocorticoids elevate blood glucose are: 1. Stimulation of hepatic gluconeogenesis. Increase the activity of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, the key enzymes of hepatic gluconeogenesis, promote muscle proteolysis to release amino acids, lipolysis to release free fatty acids, increase the substrate of hepatic gluconeogenesis, etc. 2.Inhibit the uptake and utilization of glucose by peripheral tissues. High concentrations of glucocorticoids not only inhibit the binding of insulin to its receptors, but also impair the action of the post-receptor glucose transport system in peripheral tissues. 3. Increase hepatic gluconeogen synthesis. This effect of glucocorticoids is achieved by increasing the activity of hepatic gluconeogen synthase. 4.It has a “permissive” and “synergistic” effect on the glucose-raising effect of glucagon, adrenaline and growth hormone.