Cervical cancer is the second most common malignant tumor in women and a serious threat to women’s health. “Love her, protect her” is the slogan of the “Chinese Women’s Cervical Health Promotion Program – Operation Shell”. The aim is to make women and their partners pay attention to cervical disease through publicity and education, so that they can stay away from cervical cancer and be a healthy woman. After years of scientific research, it is now very clear that persistent HPV infection is directly related to cervical cancer. There is no specific medicine to remove the virus, but it can be prevented by vaccine. HPV vaccine is the same and can be used for prevention. 1, the type of vaccine At present, there are two types of HPV vaccines for prevention worldwide, one is the quadrivalent vaccine developed by the United States Mercer, the trade name is “Gardasil” (Gardasil). It can be used against HPV types 16, 18, 6 and 11. The other is the bivalent vaccine Cervarix, developed by GSK (UK), which only targets HPV16 and HPV18 subtypes. Although the current vaccine does not cover all HPV subtypes, 70% of cervical cancers are associated with HPV16 and HPV18, while HPV6 and HPV11 are closely related to the development of genital warts. The difference between the two vaccines is that the former can be used for men in addition to women. 2. The best time to get the HPV vaccine The American College of Obstetricians and Gynecologists (ACOG) recommends that all women between the ages of 9 and 26 be vaccinated, preferably before they have sexual intercourse. The CDC’s Committee on Immunization Practices (ACIP) recommends vaccination at age 11 or 12, with catch-up vaccination available for women aged 13-26 who have already had sex. The World Health Organization (WHO) recommends vaccination for 9-12 year olds. The U.S. Food and Drug Administration (FDA) has approved the HPV vaccine for ages 9-26. It is generally considered that adolescent females are the preferred population for vaccination. Is the vaccine effective for women >26 years old or who are already sexually active? Some studies have also concluded that HPV vaccination for women aged 26-45 years can still reduce the incidence of cervical precancerous lesions. Therefore, the development and application of HPV vaccine has opened a new door of hope for the prevention and treatment of cervical cancer and women’s health.