For cases where oral medication is ineffective or relapses after medication, and where medication is not suitable, the following methods of treatment are available: 1. Intravascular local injections: Not suitable for giant hemangiomas. The injected drugs are ① hormone corticosteroids, mainly trimethoprim. There is a retrospective study, 155 cases of head and neck hemangioma, 10mg/ml, <3mg/kg, once a month, 3-6 times, mass reduction >50% as effective, total efficiency 85%, deep hemangioma 80%, mixed 60%; the main side effects are necrosis of eyelid or lip skin, occlusion of optic artery and adrenal hypofunction. ② Pingyangmycin , the main side effects of pulmonary fibrosis and bone marrow suppression. 2.Hemangioma surface coating：Adapted to superficial cases. ① hormonal ointment such as beclomethasone propionate cream; ② immune enhancing drugs, imiquimod ointment (imiquimod), a retrospective study of 18 cases, 60% effective, mixed hemangioma 50% effective; ③ timolol gel, a beta-blocker, 0.5%, twice a day, 6-12 weeks, if 4-6 weeks no effect, need to discontinuation of the drug. In a retrospective study of multiple medical centers, 73 cases, mean 4 months of age, with superficial hemangiomas of the head and neck, were effective for 3 months with >45% reduction of the mass and all but 1 case. The main side effects were infection and local necrosis. 3. Laser and radiofrequency: Suitable for superficial and ulcerative degenerative stage, the indications should be selected appropriately. Pulsed dye laser (PDL) is the most commonly used laser for hemangioma treatment. Oxyhemoglobin is more in hemangioma than surrounding tissues. Selective photothermolysis is the selective absorption of laser energy by certain specific tissue components such as oxyhemoglobin, and the heat generated by the thermal effect destroys these specific tissue components, causing coagulation within the hemangioma lesion. The body’s own immune and metabolic systems can absorb and excrete these destroyed tissue fragments to treat pigmented diseases. There are various lasers, radiofrequency and photoelectric ablation such as Nd:YAG (KTG), IPL, etc. In the last decade or so, a large number of lasers of different wavelengths have emerged in the medical field. These lasers have achieved good results in the treatment of vascular diseases (e.g., nevus, hemangioma, capillary dilation). In order to achieve selective photothermolysis, the proper wavelength, pulse width, and energy density must be chosen. Different tissues absorb different wavelengths of laser light, and we usually want the vast majority of the laser photon energy to be absorbed by the target group of tissues (good results) and less by the surrounding tissues (small scars). Side effects include transient edema, hyperpigmentation and depigmentation, local pain, scarring, and occasionally ulceration and severe bleeding. More research literature, not many positive conclusions, the effect is more related to the equipment and doctor’s experience. 4, P32 radioactive dressing, freezing, cautery, will leave large and obvious scars, now less used. 5.Surgical excision: Which hemangiomas are suitable for surgical excision? The following can be considered: hemangioma with scar or skin laxity after degeneration, hemangioma with a tip, small periorbital hemangioma, degenerative lesions in areas with cosmetic impact, large periorbital hemangioma, refractory ulcerative hemangioma, nasal tip area, or large side effects of drugs, or acceptable scar after surgery. Surgical treatment is reliable and exact, but it will leave scars, and the pros and cons need to be carefully communicated between parents and doctors. 6.Vascular embolization: It is suitable for large hemangioma of internal organs or deep, especially hemangioma of liver, and the effect is better.