An important reason for this situation is the misunderstanding that “Chinese medicine is non-toxic”, so that there are irregularities such as random combination of medicines, random increase of dosage, random extension of treatment course, etc. This disorderly use of medicines has led to a great waste of medical resources and a serious shortage of medical insurance funds. This disorderly use of medicine has led to a great waste of medical resources and a serious shortage of medical insurance funds, and even endangered people’s health. Is Chinese medicine really non-toxic? No, it is not. The duality of drugs is one of the basic laws of drug action, and proprietary Chinese medicines are no exception. They can play a role in preventing and treating diseases, but they can also cause adverse reactions, which is known as “medicine is three parts toxic”. Chinese medicines have different degrees of toxic side effects, especially some Chinese medicines taken for too long, taking too large a dose, the toxic side effects are more obvious, such as: Yunnan Baiyao, Niuhuang detoxification pill, antelope detoxification pill, six gods pill, etc., easy to cause allergic reactions, the light itchy skin, fixed erythema, etc., serious exfoliative dermatitis, upper gastrointestinal bleeding and visceral damage, etc., in recent years, Chinese medicines caused by the liver In recent years, the adverse events of liver and kidney function damage caused by pCms have occurred from time to time; the pCms containing cinnabar, borax, Angong Niuhuang Wan, Zixue Dan, Guanxin Suhe Wan, etc., may show symptoms of chronic mercury poisoning when taken for a long time. The safety of proprietary Chinese medicine has a long history, is widely used, convenient to carry, and popular among patients. A lot of research and clinical practice show that the safety of proprietary Chinese medicine is high under reasonable use. The rational use includes the correct identification and selection of drugs, dosage, treatment course, contraindications, combined use and other aspects, any of which may cause adverse drug events, so the rational use of drugs is an important guarantee of the safety of the application of proprietary Chinese medicines. The main reasons for adverse reactions of pCms are as follows: the pharmacological effects of pCms or toxic components; patients are atopic, intolerant to certain drugs, allergic, etc.; prescriptions and symptoms do not match, such as improper identification or inaccurate grasp of indications; long-term or overdose, especially those containing toxic Chinese herbs, such as vermilion, stigmaster, sophora, Chuan Wu, Cao Wu In particular, Chinese patent medicines containing toxic Chinese herbs, such as Vermilion, Xiong Huang, Radix et Rhizoma, Chuan Wu, Cao Wu, Bei Dou Ge, etc., can be poisoned by overdose; inappropriate combination of Chinese and Western medicines. Adverse reactions of proprietary Chinese medicines can be manifested as one or several symptoms of multiple systems such as digestive system, respiratory system, circulatory system, nervous system, blood system, skin mucous membrane system and urinary system. Therefore, the use of proprietary Chinese medicines should be guided by the theory of Chinese medicine, and the medicine should be administered according to evidence-based treatment, rather than simply using them blindly without evidence-based treatment according to the indications in the drug manual. In particular, we should pay attention to the treatment of “different diseases with the same treatment” or “different treatment with the same disease” and use the right medicine in order to achieve the rational application of proprietary Chinese medicine. (1) Basic principles of clinical application (1) Identification and analysis of disease symptoms based on Chinese medicine theory, identification and analysis of disease symptoms, determination of specific treatments based on the symptoms, and selection of appropriate proprietary Chinese medicines based on the treatments. (2) Combination of identification and diagnosis: Combination of identification and diagnosis of diseases in TCM, and combination of identification and diagnosis of diseases in Western medicine, and selection of corresponding proprietary Chinese medicines, instead of selecting proprietary Chinese medicines only according to Western medicine diagnosis. (3) Selection of dosage form: Select the appropriate dosage form according to the patient’s physical strength, the severity of the disease and the characteristics of various dosage forms. (4) Determination of dosage: For pCms with clear dosage, overdose should be used carefully; for pCms with dosage range, the elderly should take a small value. (5) Reasonable choice of route of administration: do not use injection if it can be administered orally; do not use intravenous if it can be administered intramuscularly. When the disease is complex and one proprietary Chinese medicine cannot satisfy all the symptoms, multiple proprietary Chinese medicines can be used in combination; the combination of multiple proprietary Chinese medicines should follow the principle of complementary medicinal effects and the principle of increasing effectiveness and reducing toxicity; in principle, proprietary Chinese medicines with the same or basically the same functions should not be used in combination; drugs with harsh medicinal properties or toxic components should be avoided for repeated use; when combining medicines, pay attention to the taste of each proprietary Chinese medicine. When combining medicines, it is necessary to pay attention to the contraindications between the flavors and components of proprietary Chinese medicines; the combination of internal and external use of proprietary Chinese medicines can be used for some diseases. (2) Principles of combined use of Chinese medicine injections The combined use of two or more Chinese medicine injections should follow the principles of complementary efficacy of the main treatment and increase efficiency and reduce toxicity, conform to the requirements of traditional Chinese medicine compounding theory, and have no contraindications; be cautious in the combined use of drugs, and consider the interval of Chinese medicine injections and drug interactions if combined use is really necessary; the simultaneous use of two or more Chinese medicine injections is strictly prohibited and should be used separately. They should be used separately. (3) The principle of combined use of proprietary Chinese medicine and western medicine The combination of Chinese and western medicine is an important part of the combination of Chinese and western medicine, but the combination of Chinese and western medicine is never simply Chinese medicine plus western medicine, how to achieve the rational use of Chinese and western medicine is an important issue that we need to seriously consider and explore, only the coherence and integration of Chinese and western medical theory will receive good therapeutic effect. If there is no clear contraindication to the use of Chinese and Western medicines, they can be used in combination; if the route of administration is the same, they should be used separately; avoid the joint use of Chinese and Western medicines with similar side effects; avoid the joint use of Chinese and Western medicines with adverse interactions. (4) The principle of combined use of Chinese and Western medicine injections is to be used cautiously, to fully consider the interaction between drugs, to reduce the type and dose of combined drugs as much as possible; to choose different routes of administration as much as possible; when drugs must be used by the same route, Chinese and Western medicines should be used separately, and mixed combinations are strictly prohibited. The use of proprietary Chinese medicines needs to be regulated, which requires the cooperation of multiple departments and close cooperation, and is a complex system project. First of all, we should work on the top-level design of medical reform and medical insurance to make it more reasonable, and truly respect and love patients from the policy level, so that hospitals and doctors do not have worries, so that the people have a sense of security; strengthen medical ethics education, improve the professional ethics of doctors; strengthen the training of Chinese medicine knowledge, and develop guidelines for the use of proprietary Chinese medicines. The medical practice should be standardized, and if necessary, an access system should be implemented to hold a certificate; the monitoring of safety indicators of proprietary Chinese medicines should be strengthened, and the reporting system of adverse reactions to proprietary Chinese medicines should be improved; the supervision of the use of proprietary Chinese medicines should be increased. Only by linking up the upper and lower levels and taking concerted efforts can we ensure the reasonable use of pCms.