Lupus erythematosus is a non-specific autoimmune disease of the organs. Lupus erythematosus can be viewed as a spectrum of diseases, with cutaneous lupus erythematosus, in which the lesions are limited to the skin and other organs are less severely damaged if at all, and systemic lupus erythematosus, in which the lesions involve multiple organs and systems, at one end of the spectrum. The line between the two is not clear, and true cutaneous lupus erythematosus is rare, while systemic lupus erythematosus is common. Lupus erythematosus is a non-specific autoimmune disease of organs, with complex immunologic changes, including cytokine secretion, production of multiple autoantibodies, and dysfunction of immune complex clearance, etc. The dysfunction is so extensive that it affects almost the entire immune system. Commonly used drugs for the treatment of cutaneous lupus erythematosus include chloroquine or hydroxychloroquine, thalidomide, etc. Commonly used drugs for the treatment of systemic lupus erythematosus include prednisone, cyclophosphamide, cyclosporin, etc. It is recommended that patients with lupus erythematosus should consult regular hospitals for treatment under the guidance of specialists, and medications should be used according to the doctor’s instructions.