Multiple cysts in the liver, if there are too many cysts and they are large, they may compress the liver parenchyma, resulting in atrophy of liver parenchyma and causing the possibility of liver insufficiency or liver failure, and multiple cysts in the liver should be observed in time. If the patient is diagnosed with multiple cysts in liver by upper abdominal ultrasound or upper abdominal CT, and the possibility of metastatic tumor is excluded, it is suggested that the patient should review the upper abdominal ultrasound every six months or one year to see the change of the diameter of liver cysts, if the diameter of liver cysts is less than 5cm, the patient can review the upper abdominal ultrasound every six months or one year to continue observation. If the patient’s upper abdominal ultrasound indicates that the maximum diameter of the liver cyst is more than 5 cm, ultrasound-guided percutaneous and transhepatic hepatic cyst puncture and drainage can be chosen, and after the drainage is completed, anhydrous alcohol is injected through the catheter to destroy the cyst wall, but the recurrence rate is higher; another method is laparoscopic decortication and drainage of liver cysts, which is suitable for cases where the liver cysts are located on the surface of the liver and are multiple. After laparoscopic access, a small incision is made at the top center of the cyst to release the cystic fluid and remove as much of the cyst wall as possible, and the patient is given abdominal drainage, which can recover or heal after a few days of treatment, with a low recurrence rate. If necessary, partial hepatectomy can also be performed with the most complete results. For patients with advanced polycystic liver, liver transplantation can only be considered. In another special case, patients need to observe whether there are multiple small cysts in both kidneys at the same time during the upper abdominal ultrasound examination, and if there are multiple small cysts in both kidneys at the same time, polycystic liver and polycystic kidney may be considered, and these diseases are hereditary diseases, and there is no special drug treatment at present, and patients will have liver failure and kidney failure at the later stage, so early detection and early treatment, patients generally have a better prognosis. The prognosis is generally better with early detection and treatment.