The cause of urticaria is directly related to a variety of allergic factors. Patients develop local tissue edema as a result of increased local vascular permeability due to a variety of allergic factors. For patients with acute urticaria, oral antihistamines are the first choice. Clinically, loratadine is one of the more commonly used drugs with fewer side effects. The vast majority of patients with acute urticaria can receive relatively good results by simply taking oral loratadine. Of course, there are some patients for whom oral loratadine does not bring the hives under effective control. For such patients, they can also be treated with topical application of glyburide lotion and glucocorticoid ointment, as well as intravenous application of glucocorticoids and calcium gluconate at the hospital. However, patients who have frequent urticaria attacks can always keep loratadine at home.