Uric acid is the end product of purine metabolism. The saturation and concentration of uric acid in the body is about 420 μmol/L (7 mg/dl) at 37°C. Above this concentration, hyperuricemia is considered, and long-term hyperuricemia may lead to gout. Clinically, there are primary hyperuricemia and secondary hyperuricemia. The treatment of primary hyperuricemia and gout to lower uric acid includes: 1. General treatment: control the total calorie of diet; limit the consumption of alcohol and high purine food; drink a lot of water to increase the excretion of uric acid; use drugs that inhibit uric acid excretion such as thiazide diuretics with caution; avoid triggering factors and actively treat related diseases. 2.Treatment of hyperuricemia: The aim is to maintain the normal level of uric acid. Mainly include: uric acid excreting drugs such as benzbromarone, drugs to inhibit uric acid production such as allopurinol, alkaline drugs such as sodium bicarbonate, new uric acid lowering drugs such as selective uric acid reabsorption inhibitors. 3. Treatment of acute gouty arthritis: After hyperuricemia develops into gouty arthritis, colchicine, non-steroidal anti-inflammatory drugs and glucocorticoids are the first-line drugs for the treatment of acute gouty arthritis and should be used early. Treatment of interictal and chronic gout attacks: For patients with frequent attacks of acute gouty arthritis, chronic gouty arthritis or gout stones, uric acid-lowering therapy should be performed. For secondary hyperuricemia, treatment should be based on active treatment of the primary disease, avoiding or reducing the use of drugs and methods that may trigger and/or aggravate hyperuricemia, and controlling the acute gouty arthritis attacks as soon as possible. Clinically, hyperuricemia and gout are often associated with metabolic syndrome and should be actively treated with a combination of antihypertensive, lipid-lowering, weight reduction and improvement of insulin resistance. Therefore, to lower uric acid, we should choose the appropriate method according to the cause and condition of the patient, and combine medication with general treatment to achieve better results.