HPV58 infection in women is self-resolving if it is a transient infection, with an average clearance time of 8 months, lasting more than 1 year in about 30% of women and 2 years in about 9% of women. The HPV58 virus is a mucosal high-risk virus and infection increases the prevalence of cervical cancer. Therefore, patients who find the virus infection are recommended to visit the gynecology or infection department of the hospital promptly and not to wait for self-healing. Patients can get a clear diagnosis through cervical cytology examination, and if there are no obvious abnormal cells, they can be treated with antiviral drugs such as interferon and reviewed in 3-6 months. In addition, because HPV virus infection is usually associated with the normal immune system of the body, it can be transmitted through sexual intercourse, direct contact, indirect contact, and mother-to-child transmission. Therefore, women infected with HPV58 must maintain good living habits and exercise moderately to strengthen the body’s resistance and promote the clearance of HPV58 positivity. Couples should pay attention to wearing condoms when having intercourse to avoid cross-infection.