The normal percentage of basophils is usually 0-1%, and in some healthy individuals it is not even present. If the ratio of white blood cells, red blood cells, platelets, hemoglobin, and neutrophils to lymphocytes is normal, a single high basophil is not a problem.
The most common cause of elevated basophils is an inflammatory response, and the etiology is usually determined in the context of clinical manifestations such as a history of allergies, and other routine blood tests. If accompanied by elevated neutrophils, this may be due to a bacterial infection. If it is accompanied by high eosinophil values, it is associated with parasites, allergic diseases, tumor-like diseases, diabetes, infectious diseases, and blood disorders.
High eosinophil ratios may cause urticaria or anaphylaxis, and some endocrine disorders and stress reactions can also cause high eosinophil values, such as hyperthyroidism, Cushing’s disease, heart attack, infection, hemorrhage, chronic granulocytic leukemia, lymphoreticular leukemia, rare basophilic leukemia, and lead poisoning. Smoking, pregnancy, and menstruation can cause physiological elevation of basophils.