Liver cancer has a high incidence rate in China, which is very harmful and difficult to treat. There are three main reasons for the difficulty of liver cancer: firstly, the prevention measures of liver cancer in China are not yet perfect and systematic; secondly, the awareness of early diagnosis is not yet popular, which makes the diagnosis of liver cancer in China generally late; thirdly, the treatment mode of liver cancer is still inadequate in terms of individualization and humanization. To solve the difficulty of liver cancer, the key is to recognize the three “most important” aspects of liver cancer. First, liver cancer is almost the most preventable cancer. Most liver cancers occur in patients with chronic viral hepatitis and other liver diseases, and preventing the spread of viral hepatitis B or C is the most effective measure to prevent liver cancer. The main transmission routes of viral hepatitis B or C are blood transmission, sexual transmission and mother-to-child transmission. Cutting off these three transmission routes is actually not difficult, but requires systematic and long-term efforts. Secondly, liver cancer is almost the easiest cancer to diagnose at an early stage. 70%-80% of liver cancer patients have significantly elevated fetoprotein in their blood, and for liver cancer without elevated fetoprotein, ultrasound examination also has high sensitivity. Therefore, if people with high risk of liver cancer can regularly test their blood fetoprotein and have ultrasound examination, most of the liver cancers can be diagnosed at an early stage. Thirdly, liver cancer is almost the most curable cancer through minimally invasive treatment. The liver is a semi-exposed organ with only a “wall” between it and the outside world, which lays the anatomical foundation for radiofrequency ablation treatment of liver cancer through a minimally invasive route. Local ablation therapy for hepatocellular carcinoma has been developed for nearly 30 years, and radiofrequency ablation therapy has become one of the three major curative tools along with hepatectomy and liver transplantation. Research shows that for small hepatocellular carcinoma patients with diameter ≤ 3.0 cm, the application of radiofrequency ablation therapy can achieve satisfactory results, especially for those who apply it regularly and repeatedly, the five-year survival rate can reach more than 80%. Knowing where the “most” hepatocellular carcinoma is, we know the direction we should strive for.