I. Concept A metabolic disease caused by abnormal purine metabolism. The main manifestations are, elevated blood uric acid, recurrent acute arthritis, common in the first metatarsophalangeal joint, and monosodium urate deposits around the joint. Elevated uric acid is the hallmark, but not all patients with gout have elevated uric acid; blood uric acid index in normal subjects: male: 5.75 mg/dl (urban), 5.58 mg/dl (rural); female: 4.67 mg/dl (urban), 4.48 mg/dl (rural); children: 3.5~4.0 mg/dl. When blood uric acid >7.0 mg/dl in male and 6.0 mg/dl in female and women >6.0 mg/dl, there is gout formation. Clinical manifestations are divided into four phases: 1. asymptomatic hyperuricemia phase; 2. acute gouty arthritis phase; 3. gout attack interval phase; 4. chronic phase. The manifestations are: 1. acute gouty arthritis with gout is a common symptom; 2. the first metatarsophalangeal joint is a common joint part of gout (accounting for 75%), followed by the knee joint accounting for 27%; 3. most attacks at night, severe pain and waking up, similar to dislocation-like pain; 4. affected joints are often red, swollen, hot and painful; similar to venous embolitis, cellulitis; 5. gout attacks, pain like dislocation-like pain; sometimes without treatment The pain can subside even after 3-7 days, with peeling at the joint, and can recur after months or years of treatment, with symptoms increasing step by step; 6. Asymptomatic in the interstitial phase, with monosodium urate (MSU) aspirated by joint fluid aspiration, as a definite diagnosis; 7. X-ray examination: no abnormal signs in the acute phase, but there can be bone defects, round cysts, osteosclerosis, and narrowing of the joint space in the chronic phase or the exacerbation phase; IV. Laboratory tests: 1. MSU is found in joint fluid; 2. The blood uric acid level is elevated, but it cannot be used as a basis for diagnosis; 3. 0.5 mg po st, stop after pain relief or gastrointestinal symptoms appear; or inject colchicine 3 mg iv st, then 1.5 mg iv daily (pay attention to prevent overflow into the vein, and tissue necrosis). 2. NSAIDs are currently preferred as a safer method, with intra-articular injections of steroids (methylprednisolone) in older patients; 3. Prevention of gouty arthritis and gout stones with small doses of colchicine 0.5 mg once daily, along with propoxur 0.5 mg twice daily and allopurinol 10 mg twice daily; 4. Diet can help uric acid excretion.