Symptoms of middle and late stage lung cancer: 1. Shoulder and back pain: depending on the location of lung cancer tumor, shoulder and back pain will appear. Generally, lung cancer growing in the apical part of lung is more likely to start shoulder and back pain. 2. Breathing difficulty: Due to the pressure of lung cancer on lung and trachea, breathing difficulty will occur, and as the tumor keeps increasing, the impact on patients will be more and more. 3.Coughing up blood: Patients with lung cancer will cough up blood in the middle stage, which is mainly caused by the rupture of nodules due to the continuous expansion of lung cancer. It is usually accompanied by pain. 4.Male breast enlargement: Among male lung cancer patients, about 20% of them will have breast enlargement, which is mainly caused by lung cancer slowly becoming bigger and arching up the breast. 5.Fever: Generally, lung cancer will show the symptom of pneumonia, and the older the patient is, the more serious the fever will be, and the general treatment is ineffective, or it will appear with the patient for a long time. Biological immune cell therapy for tumor is the latest tumor treatment technology after surgery, radiotherapy and chemotherapy, which is called the fourth major tumor treatment mode. Bio-immune cell therapy is to cultivate tumor-killing auto-immune cells (DC and CIK cells) through biotechnology in a high-standard laboratory and infuse them back into the patient’s body to directly kill cancer cells for the purpose of cancer treatment. Unlike traditional treatment methods, biological immunotherapy mainly mobilizes the body’s natural anti-cancer ability and restores the balance of the body’s internal environment. The large number of immune cells infused back into the body can precisely remove residual tumor cells, prevent recurrence and metastasis, enhance patients’ survival quality and prolong life, and ensure patients’ full recovery.